International Prognostic Index for Chronic Lymphocytic Leukemia (CLL-IPI)
Stratifies patients with chronic lymphocytic leukemia into four risk categories.
Advice
- The CLL-IPI categorizes patients into four risk groups from low risk to very high risk. The decision to treat should not be based on the risk score, since it has not been evaluated for that purpose.
- Indications for treatment remain the same, but higher risk patients may warrant closer initial monitoring.
Management
- Guidelines have not yet incorporated the CLL-IPI scoring system into management algorithms.
- Risk categories should be used to inform prognosis, and closer monitoring for higher risk patients should be considered.
- Notably, survival estimates were based on assessments from before the era of targeted therapies for CLL, and this should be taken into consideration when counseling patients.