MDCalc

Simon Broome Diagnostic Criteria for Familial Hypercholesterolemia (FH)

Diagnoses familial hypercholesterolemia (FH) based on clinical, genetic and family history.

Age, years

Tendon xanthomas

Patient, 1st degree relative, or 2nd degree relative

DNA-based evidence of a functional LDLR, PCSK9 and APOB mutation

Family history of premature CVD events

Myocardial infarction <50 years (2nd degree relative) or <60 years (1st degree relative)

Family history of extremely high cholesterol

>290 mg/dL (7.5 mmol/L) in adult 1st or 2nd degree relative or >260 mg/dL (6.7 mmol/L) in a child or sibling <16 years

Result:

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Advice

Consider lifestyle changes, drug therapy, family testing, and other measures to manage FH if diagnosed.

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