MDCalc

Khorana Risk Score for Venous Thromboembolism in Cancer Patients

Predicts risk of VTE for cancer patients depending on type of cancer and other factors.

Use in general cancer patients (i.e., solid tumors and lymphomas). Do not use in patients with brain tumors or myelomas.

Cancer type
Pre-chemotherapy platelet count ≥350x10⁹/L
Hemoglobin level <10 g/dL or using RBC growth factors
Pre-chemotherapy leukocyte count >11x10⁹/L
BMI ≥35 kg/m²

Result:

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Advice

The Khorana Risk Score stratifies risk well. In outpatients, VTE risk remains relatively low (~10%) even in the highest score groups.

Management

At least one author group has applied a binary version of the Khorana Risk Score in practice, using the result for clinical decision making.

Critical Actions

The Khorana Risk Score requires multiple laboratory variables, and it may not stratify as consistently or accurately in higher risk patients and those with cancers not indicated in the score.