Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, Enders F, Saksena S, Burt AD, Bida JP, Lindor K, Sanderson SO, Lenzi M, Adams LA, Kench J, Therneau TM, Day CP. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology. 2007 Apr;45(4):846-54. PMID: 17393509.

Tapper EB, Lok AS. Use of Liver Imaging and Biopsy in Clinical Practice. N Engl J Med. 2017;377(8):756-768.

A D, S W, Mh W, et al. Performance of non-invasive fibrosis scores in non-alcoholic fatty liver disease with and without morbid obesity. International journal of obesity (2005). 2021;45(10)

Arnouk J, Rachakonda VP, Jaiyeola D, Behari J. Differential outcomes and clinical challenges of nafld with extreme obesity. Hepatol Commun. 2020;4(10):1419-1429.

S Q, N A, I L, et al. Obesity modifies the performance of fibrosis biomarkers in nonalcoholic fatty liver disease. The Journal of clinical endocrinology and metabolism. 2022;107(5)

Treeprasertsuk S, Björnsson E, Enders F, Suwanwalaikorn S, Lindor KD. NAFLD fibrosis score: A prognostic predictor for mortality and liver complications among NAFLD patients. World Journal of Gastroenterology. 2013;19(8):1219-1229. doi:10.3748/wjg.v19.i8.1219.

Dr. Paul Angulo

NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score

platelets

Estimates amount of scarring in the liver based on several laboratory tests.

Estimates amount of liver scarring.

NAFLD Fibrosis Score

Graham Walker, MD, is an emergency physician practicing in San Francisco, California. Dr. Walker attended medical school at the Stanford University School of Medicine and then trained in emergency medicine at St. Luke’s-Roosevelt Hospital Center in New York City, where he was Chief Resident. He returned to the west coast as a Medical Simulation fellow and attending in Stanford’s emergency department. More relevant, of course, is that Dr. Walker is the creator and developer of MDCalc and remains active in content and calculator development, along with our many other endeavors as President of MD Aware, LLC (MDCalc’s parent company).

Graham Walker, MD

The NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score estimates amount of scarring in the liver based on several laboratory tests.

NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score Calculator

Alanine Aminotransferase

Aspartate Aminotransferase

Platelet Count

Albumin (General)

Body Mass Index

Noninvasive estimate of liver scarring in HCV and HBV patients, to assess need for biopsy.

FIB-4 Index

Screens for fibrotic NASH in individuals at high risk for NAFLD.

Fibrotic NASH Index (FNI)

Quantifies end-stage liver disease for transplant planning.

MELD Score (Original)

The American Academy of Pediatrics (AAP) focuses on the health, safety, and well-being of infants, children, and young adults. With about 67,000 members, including pediatricians, medical subspecialists, and surgical specialists, the AAP supports optimal care. Over 45,000 members are board-certified Fellows of the AAP (FAAP). Its mission is to promote children's health and well-being while supporting members' professional needs.

American Academy of Pediatrics (AAP)

The American Association for Physician Leadership&reg; (AAPL) is the world&rsquo;s oldest and largest professional association dedicated solely to maximizing physician leadership.&nbsp;From the moment physicians begin their leadership journey through the time they are seasoned leaders, AAPL provides education and training, resources and tools, and content and experiences needed to close gaps between hands-on clinical care, organization system improvements and optimized business outcomes.

American Association for Physician Leadership (AAPL)

American Association for the Study of Liver Diseases

The American College of Emergency Physicians (ACEP) represents more than 38,000 emergency physicians, emergency medicine residents and medical students. ACEP promotes the highest quality of emergency care and is the leading advocate for emergency physicians and their patients, and the public. Members may earn up to 850 continuing medical education hours every year through ACEP&rsquo;s robust catalog of peer-reviewed publications and on-demand courses presented by world-renowned emergency medicine experts.

American College Of Emergency Physicians

The American College of Gastroenterology (ACG) supports clinicians in delivering high-quality, evidence-based care to gastroenterology patients. Its mission is to advance care for those with gastrointestinal disorders through excellence, innovation, and advocacy. ACG provides members with up-to-date scientific information through annual meetings, the American Journal of Gastroenterology, training courses, and research grants, focusing on digestive health and GI disorder treatments.

American College of Gastroenterology

American College of Rheumatology

The American Gastroenterological Association (AGA), founded in 1897, provides leadership and education to over 16,000 members worldwide, all dedicated to advancing gastroenterology. The AGA&rsquo;s mission is to empower clinicians and researchers to improve digestive health through clinical guidance, practice resources, and peer-reviewed research. Key journals include Gastroenterology, Clinical Gastroenterology and Hepatology, Cellular and Molecular Gastroenterology and Hepatology, and others.

American Gastroenterological Association

American Heart Association

American Urological Association

EB Medicine is the premier provider of evidence-based clinical content and CME resources for emergency medicine practitioners.

EB Medicine

MDCalc Blog

MDCalc CME

Postgraduate Institute for Medicine

The Rome Foundation is a nonprofit organization dedicated to advancing the diagnosis and treatment of Disorders of Gut-Brain Interaction (DGBI), also known as functional gastrointestinal disorders. Its mission is to improve the lives of people with DGBI. For over 30 years, the Rome Foundation has worked with scientists and clinicians worldwide to classify and assess GI function and dysfunction, creating symptom-based criteria used in clinical trials and daily practice to guide diagnosis and treatment.

The ROME Foundation

Listen to the VACO co-creators break down how to use VACO\, what it does\, and what it doesn’t.

NAFLD (Non-Alcoholic Fatty Liver Disease) Fibrosis Score

Instructions