Simplified Endoscopic Activity Score for Crohn’s Disease (SES-CD)
Assesses severity of Crohn disease based on endoscopic findings.
Advice
- This tool should not drive therapy decisions in isolation; interpret results alongside the full clinical picture (e.g., symptoms, biomarkers, and specialist expertise) to guide management and decisions about follow-up endoscopic reassessment.
- Severity cutoffs are not universally standardized; avoid overinterpreting severity categories and focus on baseline-to-follow-up change.
- Many define endoscopic response as a score reduction of ≥50% from baseline; some define endoscopic healing as a score <3.
Management
- Currently, there are no universal management recommendations based on this score.
- If results are meeting a chosen target:
- Continuation of current therapy may be appropriate.
- Deescalation can be considered cautiously and in context.
- Partial response may necessitate:
- Optimization of the medication regimen (e.g., dose or interval adjustments).
- Assessing adherence.
- High or worsening scores may require:
- Escalation or change in therapy.
- Evaluation for drivers of nonresponse (eg., infection, medication interference).
- Additional evaluation for complications (e.g., imaging).