MDCalc

Sequential Organ Failure Assessment (SOFA)-2 Score

Assesses severity of acute organ dysfunction in critically ill adults.

SOFA-2 is newly derived and requires additional external validation; it has not yet been incorporated into major critical care guidelines and should not replace established tools, such as the original SOFA.

Brain (GCS)

See Evidence for more details.

Respiratory (PaO₂:FiO₂ ratio)

See Evidence for more details.

Cardiovascular

See Evidence for more details.

Liver (total bilirubin)

Kidney (creatinine)

See Evidence for more details.

Hemostasis (platelets)

Result:

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Advice
  • Interpret results alongside a comprehensive clinical evaluation.
  • Higher scores reflect greater organ dysfunction and are associated with higher ICU mortality risk.
  • The score supports severity assessment and standardization; it is not a prescriptive treatment algorithm or individualized mortality calculator.